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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 15, No. 9, 2016, pp. 1923-1927
Bioline Code: pr16254
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 15, No. 9, 2016, pp. 1923-1927

 en Immunomodulatory activity of methanol extract of Adansonia digitata check for this species in other resources L
Sharma, Amrish & Rangari, Vinod

Abstract

Purpose: To evaluate the immune-modulatory activities of various plant parts Adansonia digitata check for this species in other resources L. using delayed-type hypersensitivity rat model.
Methods: Defatted leaf, root bark and fruit pulp of A. digitata were extracted with methanol. Immunomodulatory activity of the methanol extracts (250 and 500 mg/kg) were evaluated in sheep RBC (SRBC)-induced delayed-type hypersensitivity model, cell mediated immune re-sponse and phagocytic activity using carbon clearance test.
Results: The extracts exhibited significant increase in delayed-type hypersensitivity reaction, indicating the ability of the extracts to stimulate T-cells. It also increased SRBC induced anti-body titer in immunesuppressed rats, and produced significant increase in phagocytic index by rapid removal of carbon particles from the blood stream.
Conclusion: These results indicate that methanol extracts of the leaf, root bark and fruit pulp of A. digitata hold promise as immunemodulatory agents.

Keywords
Adansonia digitata L.; Immuno modulation; Delayed type hypersensitivity; Humoral Antibody titre; Phagocytic index

 
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