Therapeutic effects of ciprofloxacin/bushenhuazhuo combination on chronic prostatitis|
Qu, Xiao-Wei; Shan, Zhong-Jie; Zhang, Nan & Liang, Guo
Purpose: To evaluate the clinical effect of bushenhuazhuo (a Chinese traditional medicine) in
combination with ciprofloxacin (an orthodox medicine) in chronic prostatitis (CP) therapy.
Methods: A total of 160 patients who suffered from CP and received treatment in the People’s Hospital
of Zhengzhou between April 2012 and June 2014 were selected and divided randomly into treatment
and control groups, with 80 patients in each group. Control group was given 0.25 g ciprofloxacin
hydrochloride tablets twice a day for 4 weeks. In addition to ciprofloxacin administration, patients in the
treatment group also received a dose of bushenhuazhuo preparation twice daily for 4 weeks. Clinical
outcomes, quality of life as well as lecithin body and white blood cell (WBC) count in expressed prostatic
secretions (EPS-WBC) were evaluated.
Results: Cure rates in the treatment and control groups were 90 and 72.50 %, respectively; this
difference was significant (p < 0.05). Scores for National Institutes of Health Chronic Prostatitis
Symptom Index (NIH-CPSI), WBC, and lecithin bodies in the treatment group (8.20 ± 2.20 points, 4.50 ±
1.20 points, and 28.10 ± 2.10 points, respectively) were higher (p < 0.05) than for the control group
(12.20 ± 2.20, 6.30 ± 2.20, and 23.30 ± 2.90 points, respectively). The levels of interferon (IFN)-γ and
tumour necrosis factor (TNF)-α in the treatment group (26.20 ± 3.30 and 33.80 ± 5.40 mg/L,
respectively) were lower than those in the control group (37.70 ± 3.90 and 48.40 ± 3.70 mg/L,
respectively), whereas the level of interleukin (IL)-10 in the treatment group (292.60 ± 23.70 mg/L) was
higher (p < 0.05) than that in control group (235.80 ± 25.90 mg/L).
Conclusion: Ciprofloxacin combined with the Chinese traditional medicine, bushenhuazhuo
preparation, demonstrates a marked therapeutic effect in CP. Its mechanism of action may be related to
decreased levels of IFN-γ and TNF-α and increased IL-10.
Bushenhuazhuo; Interferon – γ; Ciprofloxacin; Chronic prostatitis symptom index