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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 15, No. 10, 2016, pp. 2155-2163
Bioline Code: pr16285
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 15, No. 10, 2016, pp. 2155-2163

 en Protective effects of two Astragalus check for this species in other resources species on ulcerative colitis in rats
Soliman, Gamal A; Gabr, Gamal A; Saikhan, Fahad I Al-; Ansari, Mohd Nazam; Khan, Tajdar H; Ganaie, Majid A; Abdulaziz, Saeedan S & Alankuş-Çalışkan, Özgen

Abstract

Purpose: To investigate the anti-inflammatory activities of root extracts of Astragalus gummifera check for this species in other resources and Astragalus kurdicus check for this species in other resources , as well as their protective effects against acetic acid-induced ulcerative colitis (UC) in rats.
Methods: The roots of both species were shade-dried, pulverized to fine powder and extracted with 80 % ethanol. The extracts were lyophilized using freeze-dryer, and their anti-inflammatory effects were evaluated in rats by carrageenan-induced paw edema. In UC study, the extracts, at doses of 200 and 400 mg/kg, were given orally to rats for 5 days, with the last dose given 2 h prior to colitis induction. Histopathological studies were carried out on the colon tissues. Dexamethasone (DEX) was used as standard anti-inflammatory drug.
Results: A. gummifera (400 mg/kg) and A. kurdicus (200 and 400 mg/kg) significantly reduced carrageenan-induced edema, offered protection against UC and arrested UC-induced increases in myeloperoxidase (MPO) activity. Histological examination of colon sections also revealed evidence of extract-induced protection from UC.
Conclusion: These results suggest that A. gummifera and A. kurdicus root extracts have promising potential as sources of anti-inflammatory agents which may be useful in the treatment of UC.

Keywords
Colon ulcer; Astragalus gummifera; Astragalus. kurdicus Inflammation; Myeloperoxidase; Ulcer index

 
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