Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 15, No. 10, 2016, pp. 2183-2190
Bioline Code: pr16288
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 15, No. 10, 2016, pp. 2183-2190
© Copyright 2016 - Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria.
Chemical composition and antinociceptive effects of essential oil from aerial parts of Gundelia tournefortii L Asteraceae (Compositae) in rats|
Qnais, Esam; Bseiso, Yousra; Wedyan, Mohammad; Omari, Maryam Al- & Alkhateeb, Hakam
Purpose: To investigate the antinociceptive effect of the essential oil from the aerial parts of Gundelia.
tournefortii (EOGT) in various experimental models
Methods: The essential oil from the aerial parts of Gundelia tournefortii was extracted using steam
distillation method median lethal dose (LD50) of EOGT was evaluated using the method of Lorke.
Antinociceptive effect of EOGT in rats was carried out using chemical (formalin and acetic acid) and
thermal (hot-plate) nociceptive tests at doses of 10, 31.6, 100, 316 and 1000 mg/kg. The possible
mechanism of action of EOGT was also examined.
Results: In acute toxicity test, LD50 for EOGT was 2500 mg/kg. EOGT at test doses (10, 31.6, 100, 316
and 1000 mg/kg, orally) significantly reduced pain response in all tests in a dose-dependent manner
(p < 0.05). Glibenclamide (potassium channel sensitive to ATP antagonist) and yoimbina (α2 adrenergic
receptor antagonist), partially antagonized the antinociceptive activity induced by EOGT. However,
naloxone (opioid antagonist) and L-NAME (an inhibitor of nitric oxide synthase) did not reverse the
antinociception produced by EOGT.
Conclusion: Essential oil from the aerial parts of G. tournefortii shows significant antinociceptive
activity, which appeared to involve the participation of K+ channels sensitive to ATP and adrenergic
receptors. These findings justify in part the traditional use of the plant in the treatment of various painful
Antinociceptive; Opioid receptors; Adrenergic receptor; Essential oil; Gundelia tournefortii; Formalin test
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