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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 15, No. 11, 2016, pp. 2303-2309
Bioline Code: pr16304
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 15, No. 11, 2016, pp. 2303-2309

 en Preparation and in vitro evaluation of amoxicillin encapsulated in alginate-coated chitosan microparticles
Onuigbo, Ebele; Onugwu, Adaeze; Nwocha, Matthew; Odiase, Augustine & Attama, Anthony


Purpose: To optimize and characterize amoxicillin encapsulated in mucoadhesive alginate-coated chitosan microparticles for the treatment of gastric and duodenal ulcers caused by Helicobacter pylori check for this species in other resources .
Methods: Eighteen batches of various ratios of chitosan, sodium alginate and calcium chloride were prepared by ionotropic gelation method. The batches were optimized based on their particle size (PS) and drug encapsulation efficiency (PDEE). Optimized batches were further evaluated for in vitro drug release, bacterial susceptibility and mucoadhesion.
Results: Microparticle size ranged from 0.70 ± 0.37 to 5.25 ± 0.70 μm. Drug encapsulation efficiency ranged from 95.79 to 97.42 % while maximum drug released after 24 h was 44.79 % in simulated gastric fluid (SGF). Mucoadhesion reached a maximum of 76 % in simulated intestinal fluid (SIF). Drug release followed Higuchi model of release kinetics while the release exponent, n, was > 0.9 in all the formulations. There was a significant difference between the inhibition zone diameter (IZD) of the optimized formulations and that of a commercial brand of amoxicillin when they were tested against Salmonella typhi check for this species in other resources and Staphylococcus aureus check for this species in other resources .
Conclusion: The mucoadhesive amoxicillin microparticles may improve the treatment of gastric ulcer caused by H. pylori due to enhanced adhesion of the formulation to the pig’s ileum and the increased antibacterial property against Salmonella typhi and Staphylococcus aureus.

Amoxicillin; Gastric ulcer; Microparticles; Chitosan; Alginate; Encapsulation; Mucoadhesion

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