search
for
 About Bioline  All Journals  Testimonials  Membership  News  Donations


Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 15, No. 11, 2016, pp. 2351-2356
Bioline Code: pr16310
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 15, No. 11, 2016, pp. 2351-2356

 en A study on expression levels of matrix metalloproteinases and their inhibitors in patients with ulcerative colitis
Huang, Guo-Dong & Xiong, Jing

Abstract

Purpose: To investigate the expression levels of matrix metalloproteinases and their inhibitors in ulcerative colitis patients
Methods: In this investigation, the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) were evaluated in 50 patients with ulcerative colitis, which comprised of 36 males and 14 females. The tissue samples were obtained from the core needle of sample and evaluated using immunochemistry techniques.
Results: The prevailing MMP-9 and TIMP-1 expressions in the glandular epithelium and inflammatory cells were observed. In addition, the expressions were coupled with architectural changes in the tissues and inflammation in the lamina propria. It was also observed that the expression of MMPs and inhibitors with weak activation established the progress of ulcerative colitis. Statistical correlation between the MMP expressions and histopathological parameters was also very significant. MMP expression correlated with weaker expression of TIMPs.
Conclusion: MMPs, especially MMP-2, MMP-7 and MMP-9, may provide a potential target for controlling ulcerative colitis.

Keywords
Ulcerative colitis; Matrix metalloproteinases; Tissue inhibitors of metalloproteinases; Lamina propria; Inflammation

 
© Copyright 2016 - Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria.
Alternative site location: http://www.tjpr.org

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2022, Site last up-dated on 19-Jan-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil