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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 15, No. 11, 2016, pp. 2429-2434
Bioline Code: pr16320
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 15, No. 11, 2016, pp. 2429-2434

 en Comparison of the acute effects of Tulbaghia violacea check for this species in other resources William Henry Harvey (Alliaceae) on blood pressure and heart rate of ageing male normotensive Wistar kyoto rats and adult male spontaneously hypertensive rats
Raji, Ismaila; Obikeze, Kenechukwu & Mugabo, Pierre

Abstract


Purpose: To assess the effect of the crude methanol leaf extracts of Tulbaghia violacea William Henry Harvey (Alliaceae) on blood pressure (BP) and heart rate in ageing normotensive Wistar Kyoto rats (WKY), and compare the results obtained with those for adult spontaneously hypertensive rats (SHR).
Methods: T. violacea (5 – 150 mg/kg) and/or vehicle (dimethylsulfoxide and normal saline) were respectively and randomly administered intravenously to groups of ageing (15 months) WKY and adult (< 5 months) SHR, weighing 380 - 470 and 280 - 320 g, respectively. BP and heart rate (HR) were measured via a pressure transducer connecting the femoral artery and Powerlab equipment.
Results: T. violacea significantly and dose-dependently reduced systolic BP, diastolic BP, mean arterial pressure (MAP) and HR in both strains of rats. No statistically significant differences were however observed when the changes in BP and HR in the two rats strains were compared.
Conclusion: T. violacea was effective in reducing BP and HR in both age-induced and spontaneously hypertensive rats.

Keywords
Age; Wistar Kyoto rats; blood pressure; heart rate; Tulbaghia violacea

 
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