Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 15, No. 11, 2016, pp. 2489-2495
Bioline Code: pr16328
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 15, No. 11, 2016, pp. 2489-2495
© Copyright 2016 - Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria.
Inappropriate prescribing of proton pump inhibitors among patients in two Jordanian tertiary health facilities|
Zalloum, Needa; Abu Farha, Rana; Awwad, Oriana & Samara, Nabil
Purpose: To evaluate the current prescription pattern and appropriateness of proton pump inhibitors
(PPIs) in two of the largest tertiary hospitals in Jordan, and also to determine their utilization rate among
the admitted patients.
Methods: A retrospective cross-sectional study was conducted over 10 months (February-November
2013) at two Jordanian tertiary hospitals. A total of 193 patients, both in intensive care unit (ICU) and
non-ICU, who were receiving PPIs prescriptions as part of their drug regimen during their
hospitalization, were recruited. Patients were accessed from different hospitals’ wards (non-ICU and
ICU) using a convenient sampling technique. The appropriateness of PPIs and the rationale for their
prescription as a treatment or prevention therapy were evaluated according to the recent treatment
Results: The results showed that PPIs were being overused; only 53 patients (27.5 %) were prescribed
PPIs for a correct indication, while the remaining 140 patients (72.5 %) were receiving PPIs without any
documented valid indication. By comparing the patients according to their site of care, 52.4 % (43/82) of
ICU patients compared to 87.4 % (97/111) of medically hospitalized patient (non-ICU) were
inappropriately receiving PPIs (p = 0.000).
Conclusion: Adherence to the current practice guidelines for safe prescription of PPIs is poor. Thus,
updating physicians on the practice guidelines, participation of a clinical pharmacist in making
therapeutic decisions and modifying hospital formularies are measures that would be helpful and thus
contribute to improved healthcare in Jordan.
NSAID-induced ulcer; Overuse of medications; Proton pump inhibitor; Stress ulcer; Intensive care unit
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