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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 15, No. 12, 2016, pp. 2543-2547
Bioline Code: pr16334
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 15, No. 12, 2016, pp. 2543-2547

 en Herbal antihyperlipidemic formulation of cocoa tea: Preparation and in vivo comparison with atorvastatin
Li, Jing; Yuan, Yi-Qiang; Wang, Rui-Min; Yu, Li; Zhang, Li; Zhao, Yu-Jie; Zhang, Hua; Dong, Jia-Jian & Zhang, Jin-Ying


Purpose: To prepare and characterize a formulation containing an ethanol extract of Camellia ptilophylla check for this species in other resources leaves (cocoa tea), with a focus on antihyperlipidemic and anti-obesity activities.
Methods: An aloe vera check for this species in other resources –based formulation of an ethanol extract of cocoa tea (C. ptilophylla) was prepared. The formulation was given orally at 400 mg/kg daily to obese (high-fat diet–induced) mice for 1 month, and body weight as well as total cholesterol, triglyceride, HDL cholesterol, LDL cholesterol, and VLDL cholesterol levels were determined and compared with those of control and standard groups (the latter mice received atorvastatin at 400 mg/kg daily).
Results: At the end of treatment, the standard group exhibited 64.65 % reduction in body weight gain and the test group exhibited 48.87 % reduction, compared with control. The group that received the formulation had significantly lower levels of serum total cholesterol, triglycerides, and LDL cholesterol, and a higher level of HDL cholesterol.
Conclusion: The formulation of an ethanolic extract of cocoa tea leaves seems to exert antihyperlipidemic and anti-obesity activities comparable to those of a modern lipid-lowering agent (atorvastatin) in mice. Thus, this natural remedy has the potential to prevent or delay hyperlipidemia and the cardiovascular complications associated with diet-induced obesity.

Obesity; Lipid profile; Cocoa tea (Camellia ptilophylla) leaves; Weight management; Herbal formulation; Antihyperlipidemic; Anti-obesity

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