Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 15, No. 12, 2016, pp. 2549-2556
Bioline Code: pr16335
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 15, No. 12, 2016, pp. 2549-2556
© Copyright 2016 - Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria.
Physical characterization and kinetic modelling of matrix tablets of ketorolac tromethamol formulated with polymers and waxes|
Yener, Gülgün; Ayçiçek, Evin; Üner, Melike & Altuntaş, Ebru
Purpose: To design controlled release ketorolac tromethamol (KT) matrix tablets for increased drug
Methods: Waxes (Compritol® ATO 888, Precirol® ATO 5 and stearic acid - SA) and polymers
(hydroxypropyl methylcellulose - HPMC and xanthan gum - XG) were used in the preparation of the
matrix tablets at various excipient concentrations for controlled drug delivery. The physical properties of
the formulations were determined. Drug release profiles from the tablets were obtained and their drug
release mechanisms were characterized by kinetic modeling. Analytical quantification method of KT in
dissolution media was also validated by certain performance criteria.
Results: KT matrix tablets prepared individually with Compritol and HPMC at 30 and 40 %
concentrations, respectively, displayed the best tablet compression properties. The tablets prepared
with HPMC and XG displayed slower drug release profiles compared to the tablets prepared with waxes
in general (p < 0.05). KT release increased with increase in pH since it is a weak acid (p < 0.05).
Statistically insignificant difference was observed among all the tablets prepared with HPMC and XG in
water (p > 0.05). However, drug release from the tablets containing 40 % XG was faster than tablets
prepared with HPMC (30 and 40 %) and XG (30 %) at pH 7.2 (p < 0.05). Drug release mechanisms
from the tablets prepared with wax and polymers were non-Fickian, indicating coupled diffusion/erosion
and diffusion/polymer relaxation, respectively.
Conclusion: KT matrix tablets have been successfully formulated by direct compression method. The
findings demonstrate that both the desired physical characteristics and drug release profiles were
obtained for matrix tablets prepared with HPMC.
Ketorolac tromethamol; Controlled release; Matrix tablets; Oral drug delivery; Waxes; Polymers
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