Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 15, No. 12, 2016, pp. 2571-2578
Bioline Code: pr16338
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 15, No. 12, 2016, pp. 2571-2578
© Copyright 2016 - Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria.
Neuroprotective effect of whole-plant extract of Torilis leptophylla in isoflurane-treated rats|
Fang, Yong; Lv, Liang; Chai, Yong-Jian & Yu, Fan
Purpose: To investigate the neuroprotective effect of Torilis leptophylla (TL) extract on animals
exposed to isoflurane-induced anesthesia.
Methods: General anesthesia was induced in diabetic rats by administration of 2 % sevoflurane (v/v) in
100 % oxygen. The animals from the treatment group were orally administered TL extract. Behavioral
parameters, the explicit objection recognition index, and performance in water maze experiments were
observed. Additionally, the neuroprotection provided by the herbal extract was measured in terms of the
reduction in oxidative stress in isolated animal brain tissue.
Results: The study showed approximately 1.5-fold improvement in object recognition index of TL-extract-treated anesthetized rats compared with the control group of anesthetized animals. Additionally,
the escape latency values of the anesthetized rats in Morris water maze experiments were reduced
following TL extract treatment at all time points throughout the 5-day study protocol. Finally, biomarkers
of oxidative stress in the brain indicate that the levels of superoxide dismutase and catalase enzymes
were improved by approximately 1.43- and 1.36-fold in TL-extract-treated rats compared with those in
the control group.
Conclusion: The results of the present study show that cognitive dysfunction and brain injury
associated with enhanced oxidative stress can be reversed by the antioxidant properties of the TL
Anesthesia; Torilis leptophylla; Neuroprotection; Brain injury; Cognitive impairment; Isoflurane
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