Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 15, No. 12, 2016, pp. 2619-2628
Bioline Code: pr16344
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 15, No. 12, 2016, pp. 2619-2628
© Copyright 2016 - Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria.
Effects of oxyresveratrol and its derivatives on cultured P19-derived neurons|
Tadtong, Sarin; Chatsumpun, Nutputsorn; Sritularak, Boonchoo; Jongbunprasert, Vichien; Ploypradith, Poonsakdi & Likhitwitayawuid, Kittisak
Purpose: To modify the structure of oxyresveratrol and evaluate the obtained derivatives for effects on
Methods: Electron-withdrawing groups were selectively introduced to the aromatic ring of the core
stilbene structure. Oxyresveratrol and derivatives were then evaluated for their ability to enhance the
survival of P19 derived neuronal cells by XTT method, in comparison with the widely known
antioxidants, Trolox and ascorbic acid. Phase-contrast microscopic images of the neurons under
various conditions were also taken and analyzed.
Results: Oxyresveratrol, at a very low concentration (1 ng/mL), enhanced the survival of neurons in
both normal and serum-deprivation conditions. Higher activity was observed for the 5-formylated and t
5-carboxylated products. The potencies of these polyoxygenated stilbenes were far greater than those
of Trolox and ascorbic acid. These observations were supported by results from the examination of the
phase-contrast micrographs of the neuronal cells.
Conclusion: Oxyresveratrol and some derivatives prepared in this study demonstrate significant cell
protective activity and may be of therapeutic value, but further investigations in animals are required to
verify their neuroprotective potentials.
Oxyresveratrol; Artocarpus lacucha; Artocarpus lakoocha; Polyoxygenated stilbenes; Cell protection; Neuron
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