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Mechanism of Huiru decoction on hyperprolactinemia in rats Yang, Shufang & Wu, Bin Abstract Purpose: To investigate the anti-hyperPRL mechanism of traditional Chinese medicine Huiru Decoction (HD) in rats. Methods: The effect of HD on serum prolactin (PRL), estradiol (E2), progesterone (PGN), follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels were investigated in hyperprolactinemia (hyperPRL) rats. Furthermore, the effect of HD on hypothalamus dopamine D2 receptor, protein kinase A (PKA) and cyclic adenosine monophosphate (cAMP) levels of hyperPRL rats were investigated respectively. Results: Compared with the model group, a high dose of HD (19.2 g/kg body weight) and medium dose of HD (9.6 g/kg body weight) reduced PRL level of hyperPRL rats effectively (p < 0.01). HD increased dopamine D2 receptor (p < 0.01), reduced cAMP (p < 0.01) and PKA (p < 0.01) levels of hypothalamus in hyperPRL rats significantly. Conclusions: HD showed anti-hyperPRL activity via dopamine D2 receptor. Keywords hyperprolactinemia; Huiru Decoction; dopamine D2 receptor

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