Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 15, No. 12, 2016, pp. 2641-2645
Bioline Code: pr16347
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 15, No. 12, 2016, pp. 2641-2645
© Copyright 2016 - Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria.
Mechanism of Huiru decoction on hyperprolactinemia in rats|
Yang, Shufang & Wu, Bin
Purpose: To investigate the anti-hyperPRL mechanism of traditional Chinese medicine Huiru Decoction
(HD) in rats.
Methods: The effect of HD on serum prolactin (PRL), estradiol (E2), progesterone (PGN), follicle
stimulating hormone (FSH) and luteinizing hormone (LH) levels were investigated in hyperprolactinemia
(hyperPRL) rats. Furthermore, the effect of HD on hypothalamus dopamine D2 receptor, protein kinase
A (PKA) and cyclic adenosine monophosphate (cAMP) levels of hyperPRL rats were investigated
Results: Compared with the model group, a high dose of HD (19.2 g/kg body weight) and medium dose
of HD (9.6 g/kg body weight) reduced PRL level of hyperPRL rats effectively (p < 0.01). HD increased
dopamine D2 receptor (p < 0.01), reduced cAMP (p < 0.01) and PKA (p < 0.01) levels of hypothalamus
in hyperPRL rats significantly.
Conclusions: HD showed anti-hyperPRL activity via dopamine D2 receptor.
hyperprolactinemia; Huiru Decoction; dopamine D2 receptor
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