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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 15, No. 12, 2016, pp. 2693-2700
Bioline Code: pr16354
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 15, No. 12, 2016, pp. 2693-2700

 en Synthesis and evaluation of antioxidant and antimicrobial activities of Schiff base tin (II) complexes
Neelofar; Ali, Nauman; Ahmad, Shabir; AbdEl-Salam, Naser M; Ullah, Riaz; Nawaz, Robila & Ahmad, Sohail


Purpose: To synthesize and evaluate Schiff base Tin (II) complexes for antioxidant and antimicrobial activities
Methods: The complexes of Tin (II) chloride with various Schiff base derivative of 2-Hydroxy-1-naphthaldehyde (HN) were synthesized and characterized by various physiochemical techniques, including elemental analysis, ultraviolet–visible (UV-Vis) spectrophotometry, Fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (1H–NMR), carbon-13 nuclear magnetic resonance (13C-NMR), electron ionization mass spectrometry (EIMS) and conductance studies. Agar-well diffusion and agar-well dilution techniques were used for antimicrobial assessment. Evaluation of the antioxidant activity of the ligands and complexes was accomplished by DPPH radical scavenging assay.
Results: The results indicate coordination of deprotonated phenolic oxygen and nitrogen of azomethine with Tin (II) chloride led to the formation of stable complexes. The Tin (II) complexes showed good antimicrobial and antioxidant activities. Compounds (HNPA and [Sn(HNPA)Cl2(H2O)2) were noteworthy (p < 0.05) in this regard with antibacterial activity against Staphylococcus aureus check for this species in other resources , while [Sn(HNCA)Cl2(H2O)2 and [Sn(HNPT)Cl2(H2O)2 were active against Klebsiella pneumoniae check for this species in other resources ..
Conclusion: All synthesized Schiff bases and their Tin (II) complexes showed high antimicrobial and antioxidant activities than their corresponding ligands.

Schiff base; Ligand; Tin (II) complexes; Antimicrobial; Antioxidant; Deprotonated phenolic oxygen

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