Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 15, No. 12, 2016, pp. 2725-2731
Bioline Code: pr16359
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 15, No. 12, 2016, pp. 2725-2731
© Copyright 2016 - Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria.
Therapeutic effect of He-Wei-Tong-Xie decoction on acute pancreatitis complicated with gastrointestinal dysfunction|
Jin, Wei; Li, Qing-Jie; Song, Yang; Li, Yi-Wei & Zhang, Xiao-Yun
Purpose: To study the therapeutic effect of He-Wei-Tong-Xie (HWXT) decoction on acute pancreatitis
(AP) complicated with gastrointestinal dysfunction.
Methods: AP patients (50) were recruited from the Teaching Hospital of Chengdu University of
Traditional Chinese Medicine and randomly divided into treatment and control groups (25 per group). All
patients were evaluated at baseline, and thereafter subjected to standard therapeutic protocols,
including, fasting, gastrointestinal decompression, administration of somatostatin and omeprazole. The
patients in the treatment group also received 100 mL of HWTX by nasal route with high enema (three
times/day). Gastrointestinal function scores (stomach ache, abdominal distension, borborygmus and
defecation), and hospitalization time were evaluated on days 3 and 7 of treatment.
Results: No significant baseline differences were observed between the treatment and control groups
with respect to etiological agents and AP syndrome scores (p > 0.05). However, after 3 and 7 days of
treatment, all AP syndromes in treatment group showed significant improvement compared with the
control patients (p < 0.01). There were no significant differences in hospitalization time and rate of
recovery between the treatment and control groups (p < 0.01).
Conclusion: HWTX treatment appears to be a safe and potentially useful approach for treating AP
complicated with gastrointestinal dysfunction.
He-Wei-Tong-Xie decoction; Acute pancreatitis; Gastrointestinal dysfunction; Somatostatin; Omeprazole
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