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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-5996
Vol. 16, No. 1, 2017, pp. 75-81
Bioline Code: pr17010
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 16, No. 1, 2017, pp. 75-81

 en Effect of topical application of two Polygala tenuifolia check for this species in other resources species decoction on guinea pig skin
Miao, Mingsan; Shi, Jingjing; Guo, Lin; Wang, Tan; Xin, Weiyun & Bai, Ming

Abstract

Purpose: To investigate the effect of the topical decoction of Polygala tenuifolia Willd. and Polygala sibirica check for this species in other resources L. on a guinea pig model of sore and ulcer.
Method: A guinea pig model of sore and ulcer was produced by Staphylococcus aureus check for this species in other resources , and 80 guinea pigs were evenly divided into eight groups, consisting of five males and five females in each group. Another 10 (5 male and 5 female) guinea pigs were used as the control group. The corresponding liquid medicine was applied to the ulcer site of the animals in each group, and administered the medicine for 6 h daily with a continuous applicator for 12 d. Lysozyme content in serum was measured to determine its effects on body tissue morphology.
Results: Compared with the control group, the sore skin score of guinea pigs in each dose group of decoction of Polygala tenuifolia Willd. and Polygala sibirica L. was significantly decreased. The skin showed apparent positive pathological changes and serum lysozyme concentration increased significantly (p < 0.05).
Conclusion: Decoctions of the two Polygala tenuifolia species exert a good therapeutic effect on the guinea pig model of sore and ulcer for topical use.

Keywords
Polygala species; Topical application; Guinea pig; Skin diseases; Lysozyme; Decoction

 
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