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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 16, No. 2, 2017, pp. 271-278
Bioline Code: pr17036
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 16, No. 2, 2017, pp. 271-278

 en Bone regeneration potential of sub-microfibrous membranes with osteogenic induction of rBMSC for tissue engineering
Rhee, Yun-Hee; Oh, Seong-Hwa; Lim, Hyun-Ju; Shin, Jang-In; Kim, Chan & Oh, Chung-Hun


Purpose: To examine the biocompatibility and osteoinductive potential of sub-microfibrous membranes with cells in vitro and in vivo.
Methods: Polylactic acid (PLA) and poly-ε-caprolactone (PCL) were blended at various volume ratios (PLA:PCL = 100:0, 70:30, 50:50, 30:70 and 0:100) and each membrane form was prepared by electrospinning. Cell viability, biocompatibility, and bone regeneration were measured.
Results: The membranes from the PLA/PCL blends prepared by an electrospinning process showed a range of diameter distribution ranging from 1,580 to 550 nm. The cells of 100 % PCL membrane (smallest diameter) exhibited significantly higher adhesion and proliferation than those of the other membranes. Among the membranes from PLA/PCL blends, PCL membrane showed weak inflammatory changes in the early stages of implantation without acute or chronic inflammation. PCL membranes with osteogenically-induced cells successfully stimulated new bone formation in a rate calvarial defect model.
Conclusion: The results indicate that biodegradable PCL sub-microfibrous membrane produced by electrospinning process seems to have excellent biocompatibility, and may be used as a scaffold for bone tissue engineering.

Biocompatibility; Hard tissue; Biomaterial availability; Bone remodeling; Polylactic acid; Poly-ε-caprolactone; Osteoinductive potential; Sub-microfibrous membranes

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