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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996 EISSN: 1596-5996
Vol. 16, No. 2, 2017, pp. 305-311
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Bioline Code: pr17040
Full paper language: English
Document type: Research Article
Document available free of charge
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Tropical Journal of Pharmaceutical Research, Vol. 16, No. 2, 2017, pp. 305-311
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Physicochemical properties and lubricant potentials of Blighia sapida Sapindaceaeae seed oil in solid dosage formulations
Aloko, Sinmisola; Azubuike, Chukwuemeka P & Coker, Herbert AB
Abstract
Purpose: To investigate and compare the physicochemical properties and lubricant potentials of Blighia
sapida seed oil (BSSO) with those of magnesium stearate, a commercial lubricant.
Methods: The dried seeds of Blighia sapida (BS) powder were macerated with n-hexane for five days
to separate the oil. The physicochemical properties; solubility profile, acid value, saponification value,
iodine value of the oil were determined using standard methods. Batches of ascorbic acid tablets
compressed at same compression settings using different concentrations of BSSO as lubricant were
evaluated for their friability, weight uniformity, tablet hardness, disintegration and dissolution.
Results: BSSO had a density of 0.9 g/ml, acid value of 2.65 ± 0.20 mg KOH/g, saponification value of
141.65 ± 0.75 mg KOH/g, iodine value of 62.50 ±3.71 mg I2/g among other parameters. Fatty acid
methyl ester analysis (FAME) revealed 96.89 % of monounsaturated fatty acids and esters in the range
of C15-C23; a C23 compound, 22-tricosenoic acid was the dominant compound (46.82 %). The oil showed
excellent lubrication properties in ascorbic acid tablets at a low concentration (0.5 %), similar to 2 %
magnesium stearate. However, higher concentration (5 %) of BSSO resulted in granules that could not
be compressed into tablets. Tablets containing BSSO demonstrated satisfactory friability, weight
uniformity, hardness, disintegration and dissolution characteristics.
Conclusion: Blighia sapida seed oil is a potentially useful low-cost tablet lubricant. However, further
investigations on the excipient, including stability, toxicity, etc, are required to ascertain its suitability.
Keywords
Blighia sapida; Lubricants; Seed oil; Excipients; Ascorbic acid; Tablet properties; 22-Tricosenoic acid
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