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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 16, No. 2, 2017, pp. 313-318
Bioline Code: pr17041
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 16, No. 2, 2017, pp. 313-318

 en Preparation, characterization and antibacterial effects of eco-friendly gold nanorods
Awad, Manal A; Hendi, Awatif A; Virk, P; Ortashi, Khalid MO; Elobeid, Mai A; Merghani, Nada M; Siddiqui, Muzzammil I & Ibrahim, EM

Abstract

Purpose: To synthesize and characterize eco-friendly gold nanorods (Au-NRs) and to assess their effects against two bacterial strains.
Methods: Synthesis of eco-friendly gold nanorods was done from an aqueous solution of chloroauric acid and cetyltrimethylammonium bromide by mixing Olea europaea check for this species in other resources fruit and Acacia nilotica check for this species in other resources husk extracts with the latter as a reducing agent. The synthesis was monitored by ultraviolet–visible (UV) spectrophotmetry and a zetasizer, while the morphology of the resulting nanorods was assessed by transmission electron microscopy (TEM) and scanning electron microscopy (SEM) coupled with an energy-dispersive spectrophotometer (EDS). The effect of the prepared eco-nanorods on growth of Escherichia coli and Staphylococcus aureus bacteria were investigated by agar diffusion method.
Results: The synthesized Au-NRs were mostly rod-shaped, with mean size of 96 nm. They exhibited a potent antibacterial activity against Gram-positive and Gram-negative microorganisms ( Escherichia coli check for this species in other resources and Staphylococcus aureus check for this species in other resources ).
Conclusion: The findings suggest that the nanoformulation of the biomaterial mix of Olea europaea fruit and Acacia nilotica husk extracts is a cost-effective, eco-friendly, and non-toxic synthesis of Au-NRs which has therpeautic potential.

Keywords
Olea europaea; Acacia nilotica; Gold nanorods; Eco-friendly synthesis; Gram-positive and Gram-negative microorganisms

 
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