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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 16, No. 2, 2017, pp. 407-412
Bioline Code: pr17053
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 16, No. 2, 2017, pp. 407-412

 en Time-kill profiles and cell-surface morphological effects of crude Polycephalomyces nipponicus Cod-MK1201 mycelial extract against antibiotic-sensitive and -resistant Staphylococcus aureus check for this species in other resources
Thammawat, Sutthiwan; Sangdee, Kusavadee & Sangdee, Aphidech


Purpose: To examine the effect of crude Polycephalomyces nipponicus check for this species in other resources Cod-MK1201 mycelial extract on the viability and cell surface morphology of methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA).
Methods: Time-kill assays were conducted by incubating test bacteria with the extract and sampling at selected time points within a 24 h period. The effects of the extract on MSSA and MRSA ultrastructure were determined using a scanning electron microscope (SEM).
Results: Time-kill assay data indicate a bactericidal effect against both strains of staphylococci. The extracts were rapidly bactericidal at concentrations of 1 x MIC and 2 x MIC, achieving complete elimination of the test bacterial strains within 2 h. SEM micrographs of S. aureus taken after treatment with various concentrations of the extract revealed extensive morphological alterations to the cell surface of both MSSA and MRSA.
Conclusion: The results confirm the antibacterial activity of P. nipponicus Cod-MK1201 mycelial extract. Further research may allow this to be developed as an alternative therapy to alleviate S. aureus infection.

Antibacterial activity; Polycephalomyces nipponicus; Staphylococcus aureus; Time-kill assay; Cell surface morphology

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