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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 16, No. 2, 2017, pp. 439-443
Bioline Code: pr17057
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 16, No. 2, 2017, pp. 439-443

 en A study on the expression levels of matrix metalloproteinases and their inhibitors in patients with ulcerative colitis
Huang, Guo-Dong & Xiong, Jing

Abstract

Purpose: To investigate the expression matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in ulcerative colitis (UC) patients admitted to The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Methods: The expression of MMPs and TIMPs) was evaluated in 50 patients (36 males, 14 females) with UC who were admitted to The First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, China. Tissue samples obtained from core needle biopsies were evaluated using immunochemistry techniques.
Results: MMP-9 and TIMP-1 were strongly expressed in the glandular epithelium and inflammatory cells. In addition, the expression was coupled with changes in the tissue architecture and inflammation in the lamina propria. The expression of MMPs and weak activation of their inhibitors was related to UC progression. There were significant correlations between MMP expression and histopathological parameters (p = 0.051, R = 0.392). MMP expression correlated with weaker expression of TIMPs (p = 0.032, R = 0.0581)
Conclusion: MMP-2, MMP-7, and MMP-9 are potential targets for therapeutic control of UC.

Keywords
Glandular epithelium; Inflammatory cells; Inhibitors; Matrix metalloproteinases (MMPs); Tissue inhibitors of metalloproteinases; Ulcerative colitis

 
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