search
for
 About Bioline  All Journals  Testimonials  Membership  News  Donations


Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 16, No. 3, 2017, pp. 573-576
Bioline Code: pr17073
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 16, No. 3, 2017, pp. 573-576

 en Effect of Ecklonia kurome extract on thyroid hormone disorder in rats
Zhang, Wen-bo; Li, Ju-jin; Zhang, Hui & Jiang, Hong-wei

Abstract

Purpose: To investigate the effect of Ecklonia kurome extract (EKE) on thyroid hormone concentrations in male mice.
Methods: Mice were administered EKE by gastric intubation for 15 days. PTU or L-T4 was set as positive control. Twenty-four hours after the last administration, all animals were sacrificed by cervical dislocation. Blood was collected and serum samples assayed for T3 and T4. Furthermore, the liver was removed for biochemical analysis.
Results: T3 and T4 serum levels in mice decreased after the administration of EKE. The relative potency of EKE was calculated in terms of percent increase or decrease in thyroid hormones. Compared with the control value, the decrease in T3 concentration by a high dose of EKE was approximately 64.32 %. Compared with the control group, hepatic LPO decreased (p < 0.01) while superoxide dismutase (SOD, p < 0.01) and catalase (CAT, p < 0.01) activities were significantly increased by the high dose of EKE, thus indicating its anti-peroxidative role.
Conclusion: This suggests that EKE may be useful for the treatment of hyperthyroidism, but further studies are required to ascertain this.

Keywords
Ecklonia kurome; Thyroid hormone; Anti-peroxidative; Hyperthyroidism

 
© Copyright 2017 - Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria.
Alternative site location: http://www.tjpr.org

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2022, Site last up-dated on 19-Jan-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil