Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Vol. 16, No. 3, 2017, pp. 573-576
Bioline Code: pr17073
Full paper language: English
Document type: Research Article
Document available free of charge
Tropical Journal of Pharmaceutical Research, Vol. 16, No. 3, 2017, pp. 573-576
© Copyright 2017 - Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria.
Effect of Ecklonia kurome extract on thyroid hormone disorder in rats|
Zhang, Wen-bo; Li, Ju-jin; Zhang, Hui & Jiang, Hong-wei
Purpose: To investigate the effect of Ecklonia kurome extract (EKE) on thyroid hormone concentrations
in male mice.
Methods: Mice were administered EKE by gastric intubation for 15 days. PTU or L-T4 was set as
positive control. Twenty-four hours after the last administration, all animals were sacrificed by cervical
dislocation. Blood was collected and serum samples assayed for T3 and T4. Furthermore, the liver was
removed for biochemical analysis.
Results: T3 and T4 serum levels in mice decreased after the administration of EKE. The relative
potency of EKE was calculated in terms of percent increase or decrease in thyroid hormones.
Compared with the control value, the decrease in T3 concentration by a high dose of EKE was
approximately 64.32 %. Compared with the control group, hepatic LPO decreased (p < 0.01) while
superoxide dismutase (SOD, p < 0.01) and catalase (CAT, p < 0.01) activities were significantly
increased by the high dose of EKE, thus indicating its anti-peroxidative role.
Conclusion: This suggests that EKE may be useful for the treatment of hyperthyroidism, but further
studies are required to ascertain this.
Ecklonia kurome; Thyroid hormone; Anti-peroxidative; Hyperthyroidism
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