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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 16, No. 3, 2017, pp. 605-612
Bioline Code: pr17078
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 16, No. 3, 2017, pp. 605-612

 en Anti-inflammatory and anti-apoptotic effect of Rhodiola crenulata check for this species in other resources extract on spinal cord injury in rats
Zhang, Zhao-Bo; Xiao, Teng & Sheng, Jing-Zhang

Abstract

Purpose: To investigate the effects of Rhodiola crenulata on injured spinal cord tissue recovery due to the presence of neuroprotective constituents such as salidroside, tyrosol, rosavins, and crenulatanoside.
Methods: Effect of R. crenulata extract (RCE) at doses of 10, 20 and 50 mg kg-1 was investigated for spinal cord injury (SCI) recovery in rat. The anti-inflammatory activity was estimated by haematoxylineosin (H&E) staining and myeloperoxidase activity assay, while the anti-apoptotic effect was investigated by terminal deoxynucleotidyl transferase dUTP nick-end labelling (TUNEL) and caspase-3 activity assays in SCI tissue.
Results: RCE (10 mg mL-1) treatment resulted in a Basso, Beattie and Bresnahan (BBB) score of 14.50 ± 1.22, while negative control showed a BBB score of 6.17 ± 1.60. H&E staining in test groups treated with 20 and 50 mg kg-1 RCE showed statistically different (p < 0.05) histological scores (2.0 ± 0.37 and 1.83 ± 0.31, respectively) which are higher than those of SCI (S)-induced group. The estimates of apoptosis in SCI tissue) revealed significant differences from the normalised levels in RCE-treated groups.
Conclusion: The plant extract produced good recovery of injured spinal tissue, suggesting that further clinical trials and chemical constituent studies are warranted.

Keywords
Rhodiola crenulata; Haematoxylin-eosin; Caspase-3; Anti-inflammatory; Anti-apoptotic

 
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