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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 16, No. 3, 2017, pp. 649-656
Bioline Code: pr17084
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 16, No. 3, 2017, pp. 649-656

 en Protective effects of Naringin in a rat model of spinal cord ischemia–reperfusion injury
Cui, Yongsheng; Zhao, Wei; Wang, Xinhua; Chen, Mingxin; Zhang, Li & Liu, Zhilei


Purpose: To evaluate the activity of naringin (NAR) in a rat model of spinal cord ischemic injury (SCII).
Methods: Forty female rats were randomized into four groups: saline without occlusion (control; group I), SCII (group II), 50 mg/kg NAR (group III), or 100 mg/kg NAR (group IV) for 7 days prior to SCI insult (pre-treatment). Neurological and locomotor functions, antioxidant activity, edema and inflammatory markers were determined.
Results: Pre-treatment with NAR considerably lowered the incidence of spinal edema, lipid peroxidation products, and inflammatory markers (TNF-α, NF-p65, IL-1β, and IL-6). It also successfully reverted the antioxidative activity to near-normal levels and improved locomotor function by protecting spinal tissue from oxidative damage and inflammatory insults. NAR administration effectively downregulated the protein expression of TNF-α and NF-κB p65 subunit in spinal tissue, thus confirming its anti-inflammatory activity.
Conclusion: The results suggests that NAR exhibits neuroprotective effects by inhibiting free radical generation and downregulating inflammatory markers in an SCI rat model.

Naringin; Spinal cord injury; Locomotor function; Edema; Oxidative stress; Inflammation

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