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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-9827
Vol. 16, No. 3, 2017, pp. 723-733
Bioline Code: pr17093
Full paper language: English
Document type: Review Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 16, No. 3, 2017, pp. 723-733

 en Recent advancements in oxadiazole-based anticancer agents
Rasool, Irfan; Ahmad, Matloob; Khan, Zulfiqar Ali; Mansha, Asim; Maqbool, Tahir; Zahoor, Ameer Fawad & Aslam, Sana

Abstract

Oxadiazole ring system occupies a significant position among heterocyclic templates for medicinal compounds due to its wide spectrum of biological activities. This article entails an in-depth review of the ability of oxadiazole derivatives to induce apoptosis of cancer cells. FDA has approved a number of drugs for the treatment of different types of cancer. There is, however, a continuing need for the development of new anticancer agents due to increasing cases of drug resistance. Moreover, medicinal chemists are continuously struggling to invent selective cytotoxic agents with minimum side effects. This work reviews the significance of oxadiazole ring system and its potential to act as a template for novel anticancer agents.

Keywords
Oxadiazole ring system; Anticancer activity; Antitumor activity; Cytotoxicity; Apoptosis

 
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