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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996 EISSN: 1596-5996
Vol. 16, No. 4, 2017, pp. 819-825
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Bioline Code: pr17104
Full paper language: English
Document type: Research Article
Document available free of charge
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Tropical Journal of Pharmaceutical Research, Vol. 16, No. 4, 2017, pp. 819-825
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Rice bran water extract attenuates pancreatic abnormalities in high-fat diet-induced obese rats
Parklak, Wason; Munkong, Narongsuk; Somnuk, Surasawadee; Somparn, Nuntiya; Naowaboot, Jarinyaporn; Yoysungnoen, Bhornprom & Lerdvuthisopon, Nusiri
Abstract
Purpose: To investigate the protective potential of rice bran water extract (RBE) from Khao Dawk Mali
105 on pancreatic abnormalities in high-fat diet (HFD)-induced obese rats.
Methods: Male Sprague-Dawley rats were divided into 4 groups: control group, HFD group, and HFD
group treated with RBE at 2,205 or 4,410 mg/kg/day. After 4 weeks, body weight, glucose homeostatic
parameters, and pancreatic fat accumulation were assessed. mRNA expression levels of sterol
regulatory element-binding protein-1c (SREBP-1c), insulin receptor substrate-2 (IRS-2), glucose
transporter-2 (GLUT-2) and glucokinase (GK) genes in pancreas were also analyzed.
Results: Compared with HFD group, two doses of RBE-treated rats significantly (p < 0.05) reversed
HFD-induced obesity, hyperglycemia, impaired glucose tolerance and pancreatic triglyceride
accumulation in rats. Histological examination of HFD-induced obese rats revealed fat droplets in acinar
cells, but these alterations were ameliorated in RBE-treated rats. RBE treatment showed significantly (p
< 0.05) decreased SREBP-1c expression, and also significantly (p < 0.05) increased IRS-2, GLUT-2
and GK expressions in pancreas.
Conclusion: RBE consumption may attenuate pancreatic abnormalities by inhibiting fat accumulation,
as well as enhancing insulin sensitivity and glucose sensing in the pancreas of HFD-induced obese rats.
Keywords
Rice bran; Obesity, Pancreatic steatosis, Insulin signaling, Glucose sensor
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