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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996 EISSN: 1596-5996
Vol. 16, No. 4, 2017, pp. 885-888
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Bioline Code: pr17113
Full paper language: English
Document type: Research Article
Document available free of charge
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Tropical Journal of Pharmaceutical Research, Vol. 16, No. 4, 2017, pp. 885-888
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Effect of Prunella vulgaris L extract on hyperplasia of mammary gland in rats
Qian, Yu-xian; Wang, Lin; Yang, Xuan & Li, Xin-ke
Abstract
Purpose: To explore the effects of Prunella vulgaris L extract (PVE) on hyperplasia of mammary gland
(HMG) in rats.
Methods: Forty virgin female Wistar rats were randomly divided into normal group, control group (HMG
model), positive control group (Rupixiao Capsule, RPXC), and low-, medium- and high-dose (150, 300
and 600 mg/kg) of PVE groups. Injections of estrogen and progestogen were given at the same time to
prepare rat. Changes in nipple height were measured, while serum estradiol (E2), progesterone (P),
prolactin (PRL), follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels were evaluated
by ELISA; Uterus and ovary indices were determined.
Results: Compared with control group, PVE reduced elevated nipple height to 2.25 ± 0.09 mm (p <
0.01) and uterus index to 2.29 ± 0.41 mg/g (p < 0.01), as well as reduced the number of mammary
gland lobules and secretion in HMG rats. Compared with control group, serum E2 (2.81 ± 0.17 pmol/L),
PRL (269.38 ± 8.28 pg/mL) and FSH (0.13 ± 0.03 IU/L) levels (p < 0.01) were lowered, but serum P
(1.31 ± 0.13 ng/mL) and LH (1.73 ± 0.08 mIU/mL) levels were higher (p < 0.01) in rats treated with highdose
PVE.
Conclusion: These results suggest that PVE exerts anti-HMG effect in rats induced by estrogen and
progestogen.
Keywords
Prunella vulgaris L; Anti-inflammatory; Anti-hyperplasia of mammary gland
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