About Bioline  All Journals  Testimonials  Membership  News

Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-5996
Vol. 16, No. 5, 2017, pp. 989-996
Bioline Code: pr17127
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 16, No. 5, 2017, pp. 989-996

 en Antihyperglycaemic and hypolipidemic effect of methanol extracts of Ageratum conyzoides check for this species in other resources L (Asteraceae) in normal and diabetic rats
Atawodi, Sunday E; Adepoju, Oluwafemi A & Nzelibe, Humphrey C


Purpose: To investigate the antihyperglycaemic and hypolipidemic potential of the methanol extracts of leaf, stem and root of Ageratum conyzoides in streptozotocin (STZ)-induced diabetic rats.
Methods: The extract of each of the plant part was obtained by extraction in methanol. A total of 60 male Wistar albino rats (30 induced with diabetes and 30 normoglycaemic) were assigned into diabetic and normoglycaemic groups of 6 rats each. Methanol extracts of leaf, stem and root of Ageratum conyzoides were administered orally at a dose of 100 mg/kg to the rats for a period of 14 days, with glibenclamide as the standard drug (1 mg/kg). Fasting blood glucose and lipid profile were determined to ascertain the antihyperglycaemic and hypolipidemic activities of the different parts of the plant.
Results: Ageratum conyzoides significantly (p < 0.05) reduced fasting blood glucose (FBG) levels in diabetic rats by 38.71 ± 19.41 % (leaf), 25.64 ± 20.53 % (stem), and 34.76 ± 18.03 % (root) on day 14 of the treatment, compared with untreated diabetic rats where FBG increased by 11.33±8.91 %. Total cholesterol (leaf, 119.10 ± 8.12 mg/dl; stem, 109.28 ± 8.13 mg/dl) and triglycerides (leaf, 61.71 ± 9.37 mg/dl; stem, 72.45 ± 3.39 mg/dl) levels were also significantly (p < 0.05) lowered in diabetic rats. Low density lipoprotein cholesterol (leaf, 77.21 ± 8.12 mg/dl; stem, 64.76 ± 8.04 mg/dl; root, 79.08 ± 10.61 mg/dl) levels were significantly (p < 0.05) lowered in all treated diabetic groups compared with the untreated diabetic rats (103.19 ± 6.08 mg/dl).
Conclusion: The results from this study indicate that Ageratum conyzoides has hypoglycaemic and hypolipidemic properties in rats, and this probably justifies its reported use in the traditional management of diabetes mellitus.

Ageratum conyzoides; Diabetes mellitus; Antihyperglycaemic; Hypolipidemic

© Copyright 2017 - Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria.
Alternative site location:

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2024, Site last up-dated on 01-Sep-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Google Cloud Platform, GCP, Brazil