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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-5996
Vol. 16, No. 5, 2017, pp. 1167-1172
Bioline Code: pr17149
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 16, No. 5, 2017, pp. 1167-1172

 en Eosinophilia triggers changes in IL-5, eotaxin and IL-17, and acts as a prognostic biomarker for atopic dermatitis
Wu, Zhi-hong; Zhong, Jiang; Su, Chuan-li; Huang, Yun-shu; Huang, Tao & Xu, Zhang-jie


Purpose: To investigate the implication of eosinophilia in atopic dermatitis (AD).
Methods: A total of 139 AD patients from The First Affiliated Hospital of Guangxi University of Chinese Medicine between February 2013 and May 2015, were involved in this study. Scoring atopic dermatitis (SCORAD) index was used to evaluate the skin lesions. The levels of IL-4, IL-5, IL-13, IL-17, INF-gamma, IP-10, eotaxin and Regulated on Activation, Normal T-cell Expressed and Secreted (RANTES), were determined with commercial enzyme-linked immunosorbent assay (ELISA) kits. Eosinophil counts were carried out by granulocyte count method. Correlation between SCORAD scores and levels of cytokines was analyzed using the Spearman correlation method.
Results: SCORAD scores significantly increased in the eosinophil-positive group when compared to eosinophil-negative group (p < 0.05). Eosinophil counts correlated with SCORAD scores in the eosinophil-positive group (p < 0.05). INF-γ, IP-10 and RANTES levels were significantly higher in the eosinophil-positive group than in eosinophil- negative group, while IL-5, eotaxin and IL-17 levels significantly decreased in eosinophil-positive group (p < 0.05). In the eosinophil-positive group, IL-5, eotaxin and IL-17 levels positively correlated with SCORAD scores.
Conclusion: Eosinophilia triggers lL-5, eotaxin and IL-17 changes and acts as a prognostic biomarker for atopic dermatitis. These findings may give further insights into the pathogenesis of AD.

Atopic dermatitis; Eosinophilia; SCORAD score; Biomarker; Cytokines

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