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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-5996
Vol. 16, No. 6, 2017, pp. 1369-1376
Bioline Code: pr17175
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 16, No. 6, 2017, pp. 1369-1376

 en Investigation of hemorheological and analgesic properties of Qing-Nao tablets
Xie, Guo-qi; Su, Feng; Guo, Chang-sheng; Zhang, Xu-hui; Hao, Shao-jun; Li, Dan-dong & Zhang, Zheng-chen


Purpose: To investigate the hemorheological and analgesic potentials of Qing-Nao tablet (QNT).
Methods: Sixty animals were divided into 6 groups (n = 10 for each group): normal, control, positive and 3 QNT-treated groups (QNT-H, QNT-M, QNT-L). Animals in normal and control groups received normal saline orally, while those in positive and QNT groups were orally administered either a suspension of the contents of Nao-luo-tong capsules or QNT. Hemorheological indices, including blood viscosity, plasma viscosity, activated partial thromboplastin time (APTT), thrombin time (TT), prothrombin time (PT) and fibrinogen (FIB), were determined. Acetic acid-induced writhing, tail tenderness and hot plate tests, as well as tests on microcirculation and balance/coordination were also carried out.
Results: Acute toxicity results showed that QNT is a safe drug. Whole blood and plasma viscosities of the 3 QNT-treated groups significantly decreased (p < 0.05). However, TT levels of the 3 QNT-treated animals significantly increased (p < 0.05), whereas APTT and FIB values decreased significantly (p < 0.01). Moreover, QNT significantly increased analgesia in three animal models (p < 0.05). QNT-H also significantly improved balance and coordination abilities of mice (p < 0.05).
Conclusion: These results demonstrate that QNT improves microcirculation and analgesia, and may be a source of promising candidate drugs for the treatment of brain concussion sequelae.

Qing-Nao tablet; Hemorheological; Analgesic effects; Brain concussion sequelae; Microcirculation; Balance and coordination abilities

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