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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-5996
Vol. 16, No. 6, 2017, pp. 1377-1382
Bioline Code: pr17176
Full paper language: English
Document type: Research Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 16, No. 6, 2017, pp. 1377-1382

 en Effects of the root extract of Dipsacus asperoides check for this species in other resources (Caprifoliaceae) on locomotor function and inflammation following spinal cord injury in rats
Zheng, Peng; Cao, Faqi; Dong, Qirong; Li, Pingyuan; Yang, Zhaoyao; Liu, Xiaoyong & Wang, Lei


Purpose: The study was performed to determine the effect of Dipsacus asperoides (roots), commonly known as Xu Duan, on rats with spinal cord injury (SCI).
Methods: All the animals were separated into 3 groups: normal control; a group that received Dipsacus asperoides treatment after spinal injury, and a group that received phosphate-buffered saline after SCI. These groups allowed for determination of the effect of Dipsacus asperoides treatment on SCI-injured rats. Evaluation of locomotor function restoration based on Basso–Beattie–Bresnahan score was carried out while expressions of I-kBα and NF-kB p65 were estimated. Evaluation of pro-apoptotic protein Bax and anti-apoptotic protein Bcl-2 levels was also carried by Western blotting and densitometry.
Results: The results showed that 10-mg/kg/day dose of Dipsacus asperoides restored locomotor function in rats after a period of 4 weeks. The treatment also decreased expressions of I-kBα, NF-kB p65 and Bax, but significantly increased expression of Bcl-2 (p < 0.01) in treated rats, compared to untreated rats.
Conclusion: The results indicate that treatment with Dipsacus asperoides extract effectively mitigates spinal cord injury by attenuating inflammation and apoptosis in SCI rats.

Spinal cord injury; IKK-NFkB pathway; Bax; Bcl-2; Xu Duan; Apoptosis

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