
|
Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996 EISSN: 1596-5996
Vol. 16, No. 8, 2017, pp. 1887-1891
|
Bioline Code: pr17239
Full paper language: English
Document type: Research Article
Document available free of charge
|
|
Tropical Journal of Pharmaceutical Research, Vol. 16, No. 8, 2017, pp. 1887-1891
en |
Anti-hypertensive effect of Gastrodia elata Bl leaf extract in rats
Fang, Hua; Zhang, Wei-jing; Zhang, Jing-chao; Yang, Miao; Zhang, Fang-xiang & Zhang, Jian-ping
Abstract
Purpose: To investigate the probable antihypertensive effects of Gastrodia elata Bl. extract (GEBE) in
renovascular hypertensive rats as well as the mechanism involved in blood pressure reduction.
Methods: The two-kidney one-clip (2K1C) Goldblatt model of renovascular hypertension was used in
Wistar rats. The 2K1C group rats were treated with captopril (40 mg/kg/day), low-dose GEBE (150
mg/kg/day) and high-dose of GEBE (300 mg/kg/day) for 6 weeks by intragastric administration. Systolic
(SBP) and diastolic blood pressure (DBP) were measured by the tail-cuff method. Urine creatinine and
urea levels of the rats were measured by enzyme-linked immunosorbent assay (ELISA). Superoxide
dismutase (SOD) and malondialdehyde (MDA) levels were also evaluated.
Results: In the captopril- and GEBE-treated groups, blood pressure decreased progressively over the
course of the 6-week treatment period compared with that of the untreated (control) rats (p < 0.01).
High-dose GEBE also significantly increased plasma SOD activity but decreased plasma MDA
concentration (p < 0.05). Renal function improved following captopril and GEBE (300 mg/kg/day)
treatment (p < 0.01).
Conclusion: The results suggest that GEBE probably exerts an antihypertensive effect by inhibiting
endothelin (ET)-converting enzyme and via its antioxidant activity.
Keywords
Antihypertensive; Gastrodia elata; Goldblatt renovascular hypertension; Endothelin-1; Hypertrophy
|
|
© Copyright 2017 - Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. Alternative site location: http://www.tjpr.org
|
|