The pharmacokinetic studies of enrofloxacin were investigated in yak (
Bos grunniens
L.) after administra-tion of enrofloxacin by intramuscular route at 5 mg·kg
-1 body weight. Blood samples were collected from the jugular vein at predetermined time intervals after drug administration. Plasma was separated and ana-lysed for enrofloxacin by reverse-phase high performance liquid chromatography. Various pharmacoki-netic parameters were calculated using a non-compartmental model. The elimination half-life (t
1/2), area under plasma concentration-time curve (AUC), area under the moment curve (AUMC),mean residence time (MRT), apparent volume of distribution (V
d), total body clearance (Cl
B) and apparent first-order elimi-nation rate constant (K) of enrofloxacin were 2.79±0.60 h, 5.35±1.29 μg·h·mL
-1 , 21.50±8.60 μg·h
2·mL
-1 , 4.02±0.87 h, 3.76±0.83 L·kg
-1 , 935.09 ± 236.45 mL·h
-1 ·kg
-1 and 0.25±0.07 h
-1 , respectively after the ad-ministration of enrofloxacin. Because of faster elimination time, excellent tissue penetration, shorter half- life, low MRT after intramuscular administration of enrofloxacin at a dose rate of 5 mg·kg
-1 , it is recom-mended for use in yaks at therapeutic dose.
