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Iranian Journal of Pharmacology and Therapeutics
Razi Institute for Drug Research (RIDR) of Iran University of Medical Sciences and Health Services (IUMS)
ISSN: 1735-2657
Vol. 4, No. 2, 2005, pp. 100-104
Bioline Code: pt05022
Full paper language: English
Document type: Research Article
Document available free of charge

Iranian Journal of Pharmacology and Therapeutics, Vol. 4, No. 2, 2005, pp. 100-104

 en Prevention of Acetaminophen-Induced Mitodepression with Myrobalan (Fruit of Terminalia chebula   check for this species in other resources ) in Allium cepa   check for this species in other resources Model
HEMANT SINGH RATHORE and POOJA CHOUBEY

Abstract

Allium cepa   check for this species in other resources bulbs were grown in pure tap water (group I), in seven concentrations of acetaminophen (7.81, 15.62, 31.25, 62.50, 125, 250, 500, and 1000 ppm) in the presence (group II) and absence of my-robalan (fruit of Terminalia chebula   check for this species in other resources ) at a fix concentration of 0.10 mg/mL. Parameters of study were mean root length, mitotic index, abnormal mitosis and chromosomal aberrations and morphology of root. Acetaminophen at all concentrations except 1000 ppm where roots did not grow at all, significantly inhibited root growth and declined mitotic index, effect appeared concentration dependent (group II). In the presence of myrobalan (group III) acetaminophen-induced mitodepression could be checked significantly. No morphological i.e. shape and color changes, abnormal mitosis and any type of chromosomal aberrations could be detected in any group. Probable protective role of myrobalan is discussed.

Keywords
Allium cepa, Mitodepression, Acetaminophen, Myrobalan, Terminalia chebula

 
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Alternative site location: http://ijpt.iums.ac.ir/

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