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Iranian Journal of Pharmacology and Therapeutics
Razi Institute for Drug Research (RIDR) of Iran University of Medical Sciences and Health Services (IUMS)
ISSN: 1735-2657
Vol. 4, No. 2, 2005, pp. 124-127
Bioline Code: pt05026
Full paper language: English
Document type: Research Article
Document available free of charge

Iranian Journal of Pharmacology and Therapeutics, Vol. 4, No. 2, 2005, pp. 124-127

 en Allele Frequency of CYP2C19 Gene Polymorphisms in a Healthy Iranian Population
NEGIN ZAND, NADER TAJIK, MAHMOOD HOORMAND, ALIREZA SALEK MOGHADDAM and IRAJ MILANIAN

Abstract

Cytochrome P450 2C19 (CYP2C19) plays an important role in the metabolism and elimination of a wide range of medications. The polymorphisms of this enzyme give rise to substantial inter-individual and inter-ethnic variability in drug excretion rates and final serum concentrations. For this reason, therapeutic responses and adverse drug reactions may vary from one person to another. In this study we determined genotypes of CYP2C19 in Iranian population to compare allele frequencies with previous findings in other ethnic groups. CYP2C19 (*1/*2/*3) allelic variants were determined in 200 unrelated healthy Iranian volunteers by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assays. Six subjects (3%) were homozygous for CYP2C19*2, while 44 individuals (22%) were heterozygous. In the remainder (75%) no CYP2C19*2 was found. In addition, no CYP2C19*3 was detected in the population studied. Based on our data, there was no difference between frequency of CYP2C19 allelic variants in our study and other evaluated Caucasians (p > 0.05).

Keywords
CYP2C19, Iranian population, PCR-RFLP, Pharmacogenetics, Polymorphism

 
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Alternative site location: http://ijpt.iums.ac.ir/

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