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Iranian Journal of Pharmacology and Therapeutics
Razi Institute for Drug Research (RIDR) of Iran University of Medical Sciences and Health Services (IUMS)
ISSN: 1735-2657
Vol. 5, No. 1, 2006, pp. 27-33
Bioline Code: pt06004
Full paper language: English
Document type: Research Article
Document available free of charge

Iranian Journal of Pharmacology and Therapeutics, Vol. 5, No. 1, 2006, pp. 27-33

 en Comparative Study on Antihyperglycemic and Antihyperlipidemic Effects of Separate and Composite Extract of Seed of Eugenia jambolana   check for this species in other resources and Root of Musa paradisiaca   check for this species in other resources in Streptozotocin-Induced Diabetic Male Albino Rat


Herbal medicine development against the non-communicable disease like diabetes is one of the thrust area of research in the field of global medicine. Here we have studied the separate and composite methanolic extract of seed of Eugenia jambolana and root of Musa paradisiaca for the management of streptozotocin-induced diabetes mellitus. We have measured the fasting blood glucose level and glycogen content in liver as well as in skeletal muscle.Hyperglycemia and hyperlipidemia are two important characters of diabetes mellitus. Hyperlipidemia developed in these experimental diabetic rats was assessed by quantification of total cholesterol (TC), high-density lipoprotein cholesterol (HDLc), low-density lipoprotein cholesterol (LDLc) and triglyceride (TG) in serum. We noted that after treatment of methanolic extract of above plant parts in separate as well as in composite manner in streptozotocin-induced diabetic rat resulted a significant remedial effect on blood glucose level as well as in the quantity of liver and skeletal muscle glycogen. Serum insulin level that was diminished in streptozotocin-induced diabetic state was recovered significantly after the co-administration of extract of above plant parts. Serum lipid profile was also corrected significantly in streptozotocin induced diabetic rats after the composite extract co-administration.The recovery in all the above-mentioned parameters was more effective when we use the composite extract in comparison to the separate extract of above plant parts. None of the extract has any metabolic toxicity induction in general. So the composite extracts of above plant parts have some remedial effects against streptozotocin-induced diabetic state.

Herbal extract, Diabetes mellitus, Lipid profile, Insulin, Transaminases

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