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Modulatory Effect of Vitamin C on Genotoxic Effect of Endosulfan in Developing Albino Rats Manjula, Shimoga Durgojirao; Benjamin, Susan & Bairy, Kurady Laxminarayana Abstract The genotoxic effect of endosulfan and the modulatory effect of vitamin C in growing albino rats were studied by bone marrow micronucleus assay. Seven days old male Wistar rats were treated with 3, 6, 9, 12 mg/kg Endosulfan orally (10 pups/group), for up to 60 days, at intervals of 24h. For 2 more groups (n=10/group), Endosulfan 9 mg/kg and 12 mg/kg was administered along with vitamin C (20 mg/kg). One more group of rats were treated with cyclophosphamide as positive control. The genotoxic effect was studied by bone marrow micronuclei assay. There was an increase in micronuclei in polychromatic erythrocytes (PCE) and normochromatic erythrocytes (NCE) and a decrease in PCE and P/N ratio in endosulfan treated rats. The effect was similar to the standard mutagen cyclophosphamide. In rats treated with vitamin C and endosulfan, there was an increase in PCE and P/N ratio and decrease in micronuclei in PCE and NCE. This could be due to the antimutagenic effect of vitamin C. Keywords Endosulfan, Cyclophosphamide, Vitamin C, Bone marrow micronuclei, PCE, NCE

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