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Iranian Journal of Pharmacology and Therapeutics
Razi Institute for Drug Research (RIDR) of Iran University of Medical Sciences and Health Services (IUMS)
ISSN: 1735-2657
Vol. 5, No. 2, 2006, pp. 117-119
Bioline Code: pt06019
Full paper language: English
Document type: Research Article
Document available free of charge

Iranian Journal of Pharmacology and Therapeutics, Vol. 5, No. 2, 2006, pp. 117-119

 en The Toxic Effect of Alcoholic Extract of Citrullus colocynthis   check for this species in other resources on Rat Liver
Dehghani, Farzaneh & Panjehshahin, Mohammad Reza

Abstract

There is an increasing tendency for traditional medicine in the world. Many people prefer to take herbal products instead of chemical medicines. However, over consumption of herbal medicines has led to many unpredictable side effects.One of these traditional medicines is Citrullus colocynthis, which is used by diabetic patients as an hypoglycemic agent, but it has been reported to cause gastrointestinal disorders after consumption in some patients. Fifty rats were randomly divided into five groups (4 experimental and 1 controls). In the experimental groups a single daily dose of alcoholic extract of Citrullus colocynthis   check for this species in other resources (50, 100, 200, 400 g/kg) was administered intraperitonally. Normal saline was administered in control group. After two weeks, the rats were killed and the livers were removed and fixed with formalin (10%). Specimens were then processed and stained with H&E and Reticuline.The results indicated that there is a morphological change in liver cells including karyrrhexis, chromatolysis, and granulation of the cytoplasm. Additionally, collagen and reticular fibers were evident in liver parenchyma in high doses. Citrullus colocynthis can have toxic effects on liver cells which may induce hepatocyte necrosis and liver fibrosis. These effects were dose dependent. Further studies are necessary to clarify the issue.

Keywords
Citrullus colocynthis, Liver, Necrosis

 
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Alternative site location: http://ijpt.iums.ac.ir/

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