search
for
 About Bioline  All Journals  Testimonials  Membership  News


Iranian Journal of Pharmacology and Therapeutics
Razi Institute for Drug Research (RIDR) of Iran University of Medical Sciences and Health Services (IUMS)
ISSN: 1735-2657
Vol. 5, No. 2, 2006, pp. 145-149
Bioline Code: pt06025
Full paper language: English
Document type: Research Article
Document available free of charge

Iranian Journal of Pharmacology and Therapeutics, Vol. 5, No. 2, 2006, pp. 145-149

 en Studies on Corneal Permeation and Oculo-Hypotensive Effect of Benazepril in Chronic and Acute Models of Glaucoma
SHARMA, SUNIL; PATHAK, DHARAMPAL & GOYAL, RAMESH

Abstract

The present study was carried out to investigate the effect of benazepril on corneal permeation in goat cornea and its effect on experimentally induced acute and chronic glaucoma in rabbits. Acute glaucoma was produced by i.v. infusion of 5% glucose (15 mL/kg) in rabbits, whereas chronic glaucoma was induced by injection of alpha-chymotrypsin into posterior chamber of rabbit eye. We studied the interaction of benazepril on isolated rat ileum pre-administered with acetylcholine, the enzyme cholinesterase biochemically and on ACE levels in aqueous humor after topical application. A significant increase in intra ocular pressure (IOP) in rabbits was observed which reached to the peak of 41 ± 0.85 after 90 min. Injection of alpha-chymotrypsin produced sustained elevation of Intraocular Pressure which lasted for almost 3 months. Benazepril produced significant fall in Intraocular Pressure in normotensive as well as glucose or alpha-chymotrypsin treated rabbit eyes. It was been observed that the benazepril produced significant potentiation of responses to acetylcholine in isolated rat ileum preparation and inhibition of cholinesterase enzyme. The corneal permeation of benazepril from 0.1% solution was maximum at 15 min after which there is a decline in rate of permeation was observed. The results observed in the present study indicate that the potential ocular hypotensive activity of benazepril which may be due to inhibition of ACE (Kininase-II) and cholinesterase.

Keywords
Benazepril, Intraocular pressure (IOP), Corneal permeation, ACE inhibitor

 
© Copyright 2006 - Razi Institute for Drug Research (RIDR)
Alternative site location: http://ijpt.iums.ac.ir/

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2024, Site last up-dated on 01-Sep-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Google Cloud Platform, GCP, Brazil