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Revista Colombia Médica
Universidad del Valle - Facultad de Salud
ISSN: 0120-8322
EISSN: 1657-9534
Vol. 37, No. 4, 2006, pp. 254-257
Bioline Code: rc06053
Full paper language: Spanish
Document type: Research Article
Document available free of charge

Revista Colombia Médica, Vol. 37, No. 4, 2006, pp. 254-257

 en Study of the gastric acid anti-secretory activity of Cannabis sativa check for this species in other resources in an animal model
Germán Gabriel Castillo, Harry Mauricio Pachajoa, Sandra Eliana Villota, Edwin Zurita, Mauricio Palacios, Oscar Gutiérrez

Abstract

Introduction: There are few studies that describe the effects of cannabinoids in the gastric system, although in only one, there was the description of a gastric pH alteration.
Objective: To determine the anti-secretory effect of the species Cannabis sativa check for this species in other resources .
Methodology: In this study forty five Sprague Dawley rats were used, they were submitted to a 24 hours fasting period, after which the pylorus was ligated for 2-4 hours, according to the experimental group. Thereafter, the rats were anesthetized, their stomachs extirpated and the gastric content analyzed for volume and pH.
Results: The Cannabis extract raised the gastric pH when compared to the control group (p <0.05), with no significant differences found between the reference drug (ranitidine) and the Cannabis extract (p >0.05). There were no differences in the measured volumes.
Conclusions: These results suggest that the Cannabis sativa extract diminishes the gastric acid output.

Keywords
Cannabis; Gastric juice; Cannabinoids; Tetrahydrocannabinol.

 
 es Estudio de la actividad antisecretora de ácido gástrico del Cannabis sativa check for this species in other resources en un modelo animal
Germán Gabriel Castillo, Harry Mauricio Pachajoa, Sandra Eliana Villota, Edwin Zurita, Mauricio Palacios, Oscar Gutiérrez

Resumen

Introducción: Hay pocos estudios que describan el efecto de los cannabinoides en el sistema gástrico, pues en sólo uno se encontró referencia a alteraciones del pH gástrico.
Objetivo: Determinar el efecto antisecretor de la especie Cannabis sativa check for this species in other resources .
Metodología: Se utilizaron 45 ratas Sprague Dawley que se sometieron a un ayuno de 24 horas, al cabo del cual se les ligó el píloro durante 2 ó 4 horas según el grupo experimental. Luego, se anestesiaron, se extirparon los estómagos y se analizó el contenido gástrico en términos de volumen y pH.
Resultados: Se encontró que el extracto de Cannabis aumentó el pH gástrico con respecto al grupo control (p <0.05), sin hallar diferencias significativas entre el fármaco de referencia (ranitidina) y el extracto de Cannabis (p >0.05). El volumen medido no mostró diferencias entre los grupos.
Conclusiones: Estos resultados, sugieren que el extracto de Cannabis sativa disminuye la secreción de ácido en el estómago.

Palabras-clave
Cannabis; Jugo gástrico; Cannabinoides; Tetrahidrocanabinol.

 
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Alternative site location: http://colombiamedica.univalle.edu.co

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