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Revista Colombia Médica
Universidad del Valle - Facultad de Salud
ISSN: 0120-8322
EISSN: 1657-9534
Vol. 43, No. 3, 2012, pp. 189-195
Bioline Code: rc12031
Full paper language: English
Document type: Research Article
Document available free of charge

Revista Colombia Médica, Vol. 43, No. 3, 2012, pp. 189-195

 en Relationship between Duffy blood groups genotypes and malaria infection in different ethnic groups of Choco-Colombia
Gonzalez, Lina; Vega, Jorgee; Ramirez, Jose L; Bedoya, Gabriel; Carmona-Fonseca, Jaime & Maestre, Amanda

Abstract

Background: The negative homozygous condition for the Duffy blood group (Fy-/Fy-) confers natural resistance to Plasmo- dium vivax infection. In this direction, studies carried out in Colombia are scarce
Objective: To describe the relationship between Duffy genotypes in three ethnic communities in La Italia (Chocó) and malaria infection.
Methodology: a descriptive, cross-sectional study in symptomatic and asymptomatic malaria subjects. Sample size : Afro American, 73; Amerindian (Emberá), 74 and Mestizo, 171. Presence of Plasmodium infection was assessed by thick smear and the status of the Duffy gene by PCR and RFLP in order to identify the substitutions T-46C y A131G which origin the genotypes T/T, T/C , C/C y G/G, G/A, A/A.
Results: Infection by Plasmodium check for this species in other resources was detected in 17% with 62% due to P. falciparum and 27% to P. vivax. Duffy genotypes were significantly associated to ethnicity (p=0,003). Individuals with the C/C, A/A diplotype were exclusively infected by P. falciparum, whereas other diplotypes were infected with either species. In the Amerindian and Mestizo populations, the frequency of the T-46 allele was 0,90-1,00, among Afrocolombians this was 0,50, equal to the C allele and with absence of heterozygous At locus 131, the highest frequency of the G allele was 0,30 in Amerindians and the A allele was 0,69 in Afro- colombians.
Conclusions: In the Amerindian and mestizo populations studied, a predominance of the allele T-46 (FY+) was observed, but P. vivax was not the most common. Infection by P. vivax was out ruled in all FY- individuals.

Keywords
Duffy Blood-Group System, ethnic groups, malaria, Plasmodium fal- ciparum, Plasmodium vivax, Genotypes, PCR-RFLP, Colombia

 
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