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Revista Colombia Médica
Universidad del Valle - Facultad de Salud
ISSN: 0120-8322
EISSN: 1657-9534
Vol. 43, No. 4, 2012, pp. 267-272
Bioline Code: rc12044
Full paper language: English
Document type: Research Article
Document available free of charge

Revista Colombia Médica, Vol. 43, No. 4, 2012, pp. 267-272

 en Follow-up of the tumor load in patients with de novo chronic myeloid leukemia and in complete cytogenetic remission treated with imatinib in Colombia
Guevara, Gonzalo; González, Jaime A; Lopera, Diego E; González, Manuel; Saavedra, José D; Lobaton, José Fernando & Duque, Jorge Enrique


Objective: To evaluate the hematological, cytogenetic, and molecular responses in Colombian patients with CML chronic myeloid leukemia (CML) treated with imatinib.
Methods: Two groups of patients, one with the novo diagnostic and another in state of complete cytogenetic remission were followed for 12 months with quantitative PCR evaluations every three months and with chromosomal analysis every 6 months.
Results: The group with the novo diagnosis showed 50% of complete cytogenetic remission at 12 months while the other 50% were considered to have primary resistance. Respect the molecular analysis, 10.5% of the patients reached undetectable BCR-ABL transcripts at 12 months. In the complete cytogenetic remission group, 10.6% lost the state of complete cytogene- tic remission at 12 months, 50% reached undetectable BCR-ABL transcripts but 10% showed levels higher than 10%, which in our standardization was equal to no molecular response.
Conclusions: Despite having received the conventional dosages of 400 mg/day of imatinib, the cytogenetic and molecular responses obtained in our group of Colombian patients with CML, were lower than those in other international studies.

Philadelphia chromosome, imatinib, mini- mal residual disease, BCR-ABL.

© Copyright 2012 Colombia Médica
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