Urinary tract infection (UTI) is one of the most
common bacterial infections in childhood and causes acute and
chronic morbidity as hypertension and chronic kidney disease.
To describe the demographic characteristics,
infectious agent, antibiotic resistance patterns and empiric
therapy response of UTI in pediatric population.
This is a descriptive, retrospective study.
Were included 144 patients, 1:2.06 male to female ratio.
The most common symptom was fever (79.9%) and 31.3% had
history of previous UTI. 72.0% of the patients had positive urine
leukocyte count (>5 per field), urine gram was positive in 85.0%
of samples and gram negative bacilli accounted for 77.8% for
the total pathogens isolated. The most frequent uropathogens
isolated were Escherichia coli
and Klebsiella pneumoniae
isolates had a susceptibility rate higher than 90% to
most of the antibiotics used, but a resistance rate of 42.6% to
TMP SMX and 45.5% to ampicillin sulbactam. 6.3% of E. coli
was extended-spectrum beta-lactamases producer strains. The
most frequent empirical antibiotic used was amikacin, used in
66.0% of the patients. 17 of 90 patients who undergone voiding
cistouretrography (VCUG) had vesicoureteral reflux.
This study revealed that E. coli
was the most
frequent pathogen of community acquired UTI. We found
that E. coli
and other uropathogens had a high resistance rate
against TMP SMX and ampicillin sulbactam. In order to ensure
a successful empirical treatment, protocols should be based on
local epidemiology and susceptibility rates.