Serological and molecular analysis of parvovirus B19 infection in Mayan women with systemic lupus erythematosus in Mexico.|
Valencia, Guillermo Pacheco; Nakazawa, Yumi E Ueji; Rodríguez, Dzul Edwin A; Angulo, Ramírez Angélica V; López, Villanueva Ricardo F; Quintal, Ortiz Irma G & Rosado, Paredes Elsy P
Background: Systemic lupus erythematosus (SLE) is a systemic
autoimmune disease that mainly affects women, characterized by
the production of autoantibodies. Its causal agent is unknown, but
the combination of environmental, hormonal and genetic factors
may favor the development of the disease. Parvovirus B19 has
been associated with the development of SLE, since it induces the
production of anti-single stranded DNA antibodies. It is unknown
whether PV-B19 infection is an environmental factor that trigger or
reactivate SLE in the Mexican Mayan population.
Aim: A preliminary serological and molecular study of PV-B19
infection in Mayan women with established SLE was done.
Methods: IgG and IgM anti PV-B19 were evaluated in 66 SLE
patients and 66 control subjects, all women of Mayan origin. Viral
DNA and viral load were analyzed by qPCR.
Results: Insignificant levels of IgM were observed in 14.3% (4/28) of
the patients and 11.4% (4/35) of control subjects. IgG was detected in
82.1% (23/28) of the patients and 82.9% (29/35) of control subjects,
but were significantly higher in patients. Viral DNA was found in
86.0% (57/66) of the patients and 81.0% (54/66) of control subjects.
Viral load, quantified in 28/66 patients and 31/66 controls which
were positive for IgM and IgG, was significantly higher in controls.
Conclusion: The high prevalence of PV-B19 in Yucatan, and
the presence of IgM, IgG, and viral load in Mayan women with
established SLE suggest that PV-B19 infection could be an
environmental factor to trigger or reactivate SLE.
Autoimmunity; environmental factors; autoantibodies; Systemic Lupus Erythematosus; parvovirus B19; Parvoviridae Infections; Mayan population; Mexico