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Revista Colombia Médica
Universidad del Valle - Facultad de Salud
ISSN: 0120-8322 EISSN: 0120-8322
Vol. 48, No. 4, 2017, pp. 161-166
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Bioline Code: rc17059
Full paper language: English
Document type: Research Article
Document available free of charge
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Revista Colombia Médica, Vol. 48, No. 4, 2017, pp. 161-166
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17-hydroxiprogesterone values in healthy preterm infants
Mendoza-Rojas, Víctor Clemente; Díaz-Martínez, Luis Alfonso; Mantilla-Mora, Gerardo; Contreras-García, Gustavo Adolfo; Mora-Bautista, Víctor Manuel; Martínez-Paredes, Jhon Freddy; Calderón-Rojas, Alba Luz; Gómez-Tarazona, Carlos Augusto & Pinzón-Mantilla, Katherine
Abstract
Introduction: In preterm newborn, problems with the interpretation of
17-OHP may occur.
Objective: Evaluate 17-OHP values in healthy preterm newborns until
they reach the corrected gestational age.
Methods: Longitudinal study of 36 preterm infants with 17-OHP
evaluation using ELISA from heel blood from 3 to 5 days and thereafter
every 2 weeks until the corrected gestational age. Values adjusting
multiple variables such as gestational age, birth weight and sex, among
others were compared. The results were analyzed against 82 healthy fullterm
infants.
Results: In the first week of life, early term infants born within less
than 34 months of gestational age show 17-OHP values that are much
higher than the full term neonates. After a week, the values decrease and
stabilize, but are still higher than those of full term neonates and remain
so even at the corrected gestational age (average difference of 63.0%, CI
95%: 11.8%-115.5%). 33.6% (41 samples) of a total of 122 samples taken
from preterm infants were higher than 30 ng/mL.
Conclusions: 17-OHP values in early term infants are higher than those
in full term neonates and can be related to postnatal adaptive processes.
It is suggested that a second screening at the 37th week of corrected age
be performed.
Keywords
Neonatal screening; 17-alpha-Hidroxiprogesterone; adrenal hyperplasia congenital
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© Copyright 2017 - Universidad del Valle Alternative site location: http://colombiamedica.univalle.edu.co
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