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Revista Colombia Médica
Universidad del Valle - Facultad de Salud
ISSN: 0120-8322
EISSN: 0120-8322
Vol. 49, No. 2, 2018, pp. 164-168
Bioline Code: rc18042
Full paper language: English
Document type: Research Article
Document available free of charge

Revista Colombia Médica, Vol. 49, No. 2, 2018, pp. 164-168

 en Netrin 1 and Alpha-Methyl Acylcoenzim-A Racemase in diagnosis of prostate cancer
Koseoglu, Ersin; Tuncel, Altug; Balci, Melih; Kaya, Oguzhan; Aslan, Yılmaz; Guzel, Ozer; Yilmaz, Fatma Meric & Atan, Ali

Abstract


Objectives: To investigate serum and urine levels of Alpha-methylacyl-CoA-racemase (AMACR) and Netrin 1 in patients with and without prostate cancer and to determine whether these markers could be used as alternatives in diagnosis of prostate cancer instead of serum prostate specific antigen (PSA) levels.
Methods: One hundred and seventy five patients between 45-75 years to whom transrectal ultrasound guided biopsies were performed for abnormal serum PSA levels or digital rectal examinations were included. The levels of AMACR and Netrin 1 levels of blood and urine samples of 5 mL those were taken prior to biopsies were measured.
Results: The mean age of the patients was 62.7 ±6.4 years. Prostate cancer was detected in 40 patients (22.8%) while 135 of them (77.2%) were diagnosed as benign prostate hyperplasia (BPH). In BPH group, serum and urine levels of AMACR and Netrin 1 were 13.4 ±16.9 ng/mL; 7.1 ±3.4 ng/mL; 164.1 ±46 pg/mL and 19.5±5 pg/mL respectively. The levels of serum and urine levels of AMACR and Netrin 1 were 10.2 ±9.8 ng/mL; 6.8 ±2.5 ng/mL; 159.1 ±44.1 pg/mL and 20.1 ±5.3 pg/mL respectively in prostate cancer group. There was no statistically significant difference or correlation between these two groups serum and urine AMACR and Netrin 1 results
Conclusions: Serum and urine levels of AMACR and Netrin 1 were not found to be alternatives for serum PSA levels in the diagnosis of prostate cancer in this study.

Keywords
Netrin 1; alpha-methyl acylcoenzim-A racemase; prostate; cancer

 
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