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Revista Colombia Médica
Universidad del Valle - Facultad de Salud
ISSN: 0120-8322
EISSN: 0120-8322
Vol. 50, No. 3, 2019, pp. 215-221
Bioline Code: rc19032
Full paper language: English
Document type: Case Report
Document available free of charge

Revista Colombia Médica, Vol. 50, No. 3, 2019, pp. 215-221

 en Delftia Acidovorans check for this species in other resources pneumonia with lung cavities formation
Yildiz, Hanifi; Sünnetçioğlu, Aysel; Ekin, Selami; Baran, İrfan; Özgökçe, Mesut; Aşker, Selvi; Üney, İbrahim; Turgut, Engin & Akyüz, Sümeyye

Abstract

Case Description:
A 52-year-old female patient was admitted to our clinic with complaints of cough, sputum, fever and fatigue. The patient has been receiving immunosuppressive therapy for thrombocytopenic purpura for 5 years.
Clinical Finding:
Inspiratory crackles were heard on both hemithorax. Oxygen saturation measured with the pulse oximeter was 97%. Chest X-ray showed diffuse reticular opacities that were more prominent in the upper zones of both lungs. WBC counts were 17,600 mm3 and Platelet counts were 29,000 mm3. Thorax CT showed that there were many thin-walled cavities and millimetric nodules accompanied by ground-glass infiltrates in the upper and middle lobes. Gram staining of bronchial fluid, taken by bronchoscopy, revealed Gram-negative bacilli and intense polymorphonuclear leukocytes. The bacteria were defined as Delftia acidovorans by BD Phoenix automated system.
Treatment and outcomes:
The patient was hospitalized with suspicion of opportunistic pulmonary infections and cavitary lung disease. After the empirical treatment of intravenous piperacillin-tazobactam and oral clarithromycin, her clinical and radiological findings significantly regressed, and she was discharged with outpatient follow-up.
Clinical Relevance:
This is the first example of cavitary pneumonia due to Delftia acidovorans in an immunocompromised patient. We would like to emphasize that Delftia pneumonia should be considered in the differential diagnosis of pulmonary cavitary involvement in such patients.

Keywords
Delftia acidovorans; gramnegative bacterial infections; immunocompromised host; bacterial pneumonia; respiratory tract infections; respiratory sounds; cough; Piperacillin; Piperacillin Tazobactam drug combination; multiple pulmonary nodules; lung diseases interstitial

 
 es Neumonia por Delftia acidovorans con formación de cavidades pulmonares
Yildiz, Hanifi; Sünnetçioğlu, Aysel; Ekin, Selami; Baran, İrfan; Özgökçe, Mesut; Aşker, Selvi; Üney, İbrahim; Turgut, Engin & Akyüz, Sümeyye

Resumen

Descripción del caso:
Una mujer de 52 años llegó a la clínica con tos, esputo, fiebre y fatiga. El paciente estuvo recibiendo terapia inmunosupresora durante 5 años para el tratamiento de la púrpura trombocitopénica.
Hallazgo clínico
Se escucharon crepitaciones inspiratorias en ambos hemitórax. La saturación de oxígeno fue del 97%. La radiografía de tórax mostró opacidades reticulares difusas que eran más prominentes en las zonas superiores de ambos pulmones. Los recuentos de leucocitos fueron de 17,600 mm3 y los recuentos de plaquetas fueron de 29,000 mm3.La TC de tórax mostró muchas cavidades de pared delgada y nódulos milimétricos acompañados de infiltrados vitrales en los lóbulos superior y medio. La tinción de Gram del líquido bronquial reveló bacilos gramnegativos y leucocitos polimorfonucleares. Las bacterias fueron identificadas como Delftia acidovorans.
Tratamiento y resultados
La paciente fue hospitalizado con una sospecha de infección oportunista pulmonar y enfermedad pulmonar cavitaria. Después del tratamiento empírico de piperacilinatazobactam intravenosa y claritromicina oral, los síntomas y signos retrocedieron significativamente, y fue dada de alta con seguimiento ambulatorio.
Relevancia clínica
Este es el primer registro de neumonía cavitaria causado por Delftia acidovorans en una paciente inmunocomprometida. Enfatizamos que la neumonía por Delftia debe considerarse en el diagnóstico diferencial de la afectación de la cavidad pulmonar en tales pacientes.

Palabras-clave
Delftia acidovorans; bacterias aerobicas gram-negativas; huesped immunocomprometido; pneumonia por bacterias; infecciones del tracto respiratorio; sonidos respiratorios; tos; Piperacilina; combinación Piperacilina Tazobactam; nodulos pulmonares multiples; enfermedad pulmonar interstitial

 
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