International Journal of Reproductive Medicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
Vol. 3, No. 1, 2005, pp. 1-8
Bioline Code: rm05001
Full paper language: English
Document type: Research Article
Document available free of charge
International Journal of Reproductive Medicine, Vol. 3, No. 1, 2005, pp. 1-8
© Copyright 2005 - Iranian Journal of Reproductive Medicine
Oxidative stress and antioxidants in male infertility: a difficult balance|
Agarwal, Ashok & Prabakaran, Sushil Anandh
Infertility is one of the most stressful conditions amongst married couples. Male factor infertility is implicated in almost half of these cases. Recent advances in the field of reproductive medicine have focused the attention of many researchers to consider reactive oxygen species (ROS) as one of the mediators of infertility causing sperm dysfunction. Although, ROS is involved in many physiological functions of human spermatozoa, their excess production results in oxidative stress. Mitochondria and sperm plasma membranes are the two locations of ROS production that involves complex enzyme systems such as creatine kinase and diaphorase. ROS causes damage to the spermatozoa DNA, resulting in increased apoptosis of these cells. The production of ROS is greatly enhanced under the influence of various environmental and life style factors such as pollution and smoking. An effective scavenging system is essential to counteract the effects of ROS. Various endogenous antioxidants belonging to both enzymatic and non-enzymatic groups can remove the excess ROS and prevent oxidative stress. Since, ROS is essential for the normal sperm physiology, rationale use of antioxidants is advocated.
Reactive oxygen species, Male infertility, Oxidative stress.
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