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Iranian Journal of Reproductive Medicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433
EISSN: 2008-2177
Vol. 3, No. 1, 2005, pp. 30-35
Bioline Code: rm05006
Full paper language: English
Document type: Research Article
Document available free of charge

Iranian Journal of Reproductive Medicine, Vol. 3, No. 1, 2005, pp. 30-35

 en Anti-zona pellucida antibodies in infertile patients in relation to multiple puncture of ovaries and unexplained infertility
Arefi, Soheila; Tehrani, Mahmoud Jeddi; Akhondi, Mohammad Mehdi; Mousavi, Ali Reza; Heidari, Mahnaz; Bayat, Ahmad Ali & Tabaei, Ali Sadeghpour

Abstract

Background:Auto antibodies to zona-pellucida (AZA) seem to be important autoantibodies implicated in reproduction, with substantial role in both endocrine and reproductive functions of the human ovary. There are some debates on the relation of AZA with infertility, repeated In Vitro Fertilization (IVF) attempts, and outcome of it.
Objective: In this study, we assessed the presence of AZA in the follicular fluids (FFs) of women who underwent intra cytoplasmic sperm injection (ICSI), in relation to etiology of infertility and multiple puncture of ovaries.
Materials and Methods: In this prospective study, follicular fluids were evaluated from 96 infertile women, (19-40 years old, 31.5±5.1), who were candidates for ICSI based on the etiology of infertility. From these 80 women had explained infertility whereas 16 had unexplained infertility. All FFs were evaluated for presence of AZA by ELISA test.
Results:Twenty patients (20.8%)were positive for AZA in follicular fluid.In patients with unexplained infertility, AZA antibody in follicular fluid, was significantly higher than the group with proven etiology of infertility (p=0.001). In addition, 20.4 % of patients who had been punctured previously showed AZA in their FFs which is statistically similar to the patients who were punctured for the first time.
Conclusions: The high incidence of AZA in infertile women, especially women with unexplained infertility has to be considered. Relation of the presence AZA and repeated puncture of ovaries is still debatable. Determinations of AZA are highly recommended in evaluation of infertile couples especially in patient with unexplained infertility.

Keywords
Anti Zona Antibody, Multiple puncture of ovaries,Unexplained infertility.

 
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Alternative site location: http://www.ijrm.ir

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