International Journal of Reproductive Medicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
Vol. 4, No. 2, 2006, pp. 81-83
Bioline Code: rm06016
Full paper language: English
Document type: Research Article
Document available free of charge
International Journal of Reproductive Medicine, Vol. 4, No. 2, 2006, pp. 81-83
© Copyright 2006 - Iranian Journal of Reproductive Medicine
Case report Extragonadal germ cell tumor and male infertility|
Behrouz Ilkhanizadeh, Mohammad Taghizadieh, Mehrzad Mahzad-Sadaghiani., Farahnaz Noroozinia, Bahman Jahandideh
Background: Over recent decades a possible decrease in sperm quality and an increase in the incidence of testicular cancer have been reported in many populations. Some recent findings, as cohort studies, showed an increased risk of testicular cancer in men with abnormal semen analysis.
Case: A 30 years old man referred to our clinic with chief compliant of infertility for 3 years. Spermogram revealed azoospermia and right extratesticular intrascrotal mass was detected by ultrasound examination. Right inguinal surgical approach showed intact small sized atrophic right testis and an intrascrotal mass. In microscopic examination of the mass mixed germ cell tumor with teratoma, yolk sac and embryonal components were reported.
Conclusion: Extragonadal germ cell tumors, like their testicular counterparts are associated with primary germ cell defects. The higher incidence of antecedent infertility suggests that either congenital or acquired primary germ cell defect contributes to defective spermatogenesis and therefore, there is higher risk of cancer development in incompletely migrated germ cells. We recommend complete evaluation of cancer in patients with infertility and azoospermia.
Germ cell tumor, Extragonadal, Azoospermia
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